Researches in the field of microbiology, pathogens’ molecular biology, immunology, and immunotherapy. Searching for new therapeutics against infections.
In particular, the research focuses on:
- Development of a universal platform using non-replicating adenoviruses as universal and highly immunogenic vectors – adjuvants in combination with selected CoV-19 epitopes (SARS-COVID-19 etiological factor). The platform meant for rapid testing of protective vaccines against COVID-19 and viral diseases. Research conducted in cooperation with national (NIPH-NIH, Jagiellonian University) and foreign centers (University of Padua, Italy). Understanding COVID19 pathogenesis using the 2D and 3D research models. Head of the Project: Monika Staniszewska, assistant professor.
- Development of new and effective methods of immunotherapy in the treatment of patients with mesothelioma and melanoma using a combination therapy, i.e. an oncolytic virus encoding ICOS ligand: a factor stimulating the activation of T lymphocytes and anti-PD1 (an inhibitor of the immune checkpoint PD-1 ). Studies of the action mode of combined therapy and cancer biology. Development of new and effective methods of treating cancer patients conducted in the Sonatina Project supervised by Łukasz Kuryk, PhD (NIPH-NIH). Coordinator of the studies in the CEZAMAT laboratory: Monika Staniszewska, assistant professor. The project implemented in cooperation with foreign centers in Padua and Graz (Austria).
- Research into the synthesis and selection of antimycotics effective in the treatment of patients with fungal infections. Interdisciplinary cooperation with national (Institute of Organic Chemistry PAS, Faculty of Chemistry WUT) and foreign centers (University of Guanajuato, Tübingen).
- Assessment of the antifungal activity of fabrics useful in the area of sanitary and medical protection in the project co-funded by the National Centre for Research and Development (Fast Track Competition – Coronaviruses).
- Research focusing on the regulatory interaction of the Cal fungal calcineurin subunit (encoded by the CNB1 gene) with mast cells. Cooperation with P. Borowiecki, PhD (Faculty of Chemistry) and the team of Prof. Karl Kuchler (Medical University of Vienna). Application approach involving the development of an immunotherapeutic and antifungal strategy: calcineurin target for the proxyphylline derivative.
- Diploma supervision of WUT students. Students participate in the project researches (NSC, NCRD).